The Efficient Researcher’s Workflow: How to Read Scientific Papers Smarter with Briefio

At Briefio, we’re all about making complex information digestible and empowering you to learn smarter. If you’ve ever delved into medical research, particularly about new treatments or interventions, you’ve likely encountered terms like “Randomized Controlled Trials” (RCTs). These are often called the “gold standard” of evidence. But within RCTs, there’s a critical distinction in how results are analyzed that can completely change your interpretation: Intention-to-Treat (ITT) versus Per-Protocol (PP) analysis. Understanding this difference is not just for statisticians; it’s essential for anyone who wants to truly grasp the real-world implications of medical research. Think of it as a key to unlocking deeper insights from the data. The Problem: Life Isn’t Perfect (and Neither are Clinical Trials) Imagine a clinical trial testing a new blood pressure medication. Participants are randomly assigned to either the new drug or a placebo. This randomization is crucial because it ensures the groups are initially comparable, minimizing bias. But then, life happens: If you only analyze the data from patients who perfectly followed the rules, you’re looking at a very specific, often unrealistic, subset. This is where ITT and PP come in. Per-Protocol (PP) Analysis: The “Ideal World” Scenario What it is: Per-Protocol analysis only includes data from participants who strictly adhered to the study protocol – meaning they took all their assigned medication, completed all visits, and had no major deviations. The catch: While it aims to show the maximum possible effect of a treatment under ideal conditions (its “efficacy”), it has a major flaw for real-world learning: it breaks the power of randomization. When you cherry-pick only the “perfect” participants, the groups you’re comparing are no longer truly random. Patients who drop out due to side effects, for example, are inherently different from those who tolerate the treatment well. Excluding them can make a treatment look much better than it actually is, because you’re essentially removing the patients for whom it didn’t work or caused problems. Think of it like this: Imagine a fitness challenge. A Per-Protocol analysis would only count the participants who finished every single workout, ate perfectly, and never missed a day. While their results might be impressive, they don’t reflect the experience of everyone who started the challenge. Intention-to-Treat (ITT) Analysis: The “Real World” Truth What it is: Intention-to-Treat analysis analyzes participants based on their initial randomized assignment, regardless of whether they actually completed the intervention, adhered to it, or even dropped out. Why it’s the gold standard for learning: Think of it like this: In our fitness challenge, an Intention-to-Treat analysis would include everyone who signed up, even if they dropped out after a week. Their results might not be as dramatic as the “perfect” participants, but they give a much more accurate picture of the overall success rate of the program for everyone who tried it. Your Briefio Takeaway: Always Look for ITT! When you’re consuming medical information, especially from RCTs, make it a habit to check how the data was analyzed. Understanding the difference between ITT and PP isn’t just academic; it directly impacts how you interpret research and, ultimately, how you understand what works (and what doesn’t) in the real world. At Briefio, we believe that informed learning starts with understanding the nuances, and this distinction is a perfect example. What other tricky aspects of research interpretation would you like us to simplify for your learning journey? Let us know in the comments!

Are you a science enthusiast with a passion for communication and a desire to bridge the gap between groundbreaking research and patient care? Medical Affairs might just be the perfect fit for your career. This dynamic field within the pharmaceutical and biotech industry offers a unique opportunity to leverage your scientific expertise in a non-commercial setting. But where do you start, and what roles are best for someone new to the field? As someone who interviews candidates for Medical Affairs positions, I’m often asked these questions. Let’s explore some common entry points and what it takes to succeed. Common Entry-Level Roles in Medical Affairs While the Medical Affairs landscape is diverse, three roles often serve as excellent starting points for a career in this field: Medical Science Liaison (MSL) Who it’s for: If you thrive on scientific exchange, enjoy building relationships, and are comfortable traveling frequently, the MSL role could be your calling. MSLs are the scientific face of the company, engaging in peer-to-peer discussions with Key Opinion Leaders (KOLs) and other healthcare professionals to share scientific information and gather insights. What we look for: Medical Information Specialist Who it’s for: If you have a meticulous eye for detail, excellent research skills, and a talent for clear scientific writing, a Medical Information Specialist role might be an ideal fit. This position is typically office-based and involves responding to unsolicited requests for medical information from healthcare professionals and consumers. What we look for: Medical Advisor Who it’s for: Medical Advisors are the strategists of the Medical Affairs department. While often requiring some prior industry or Medical Affairs experience, it can be an entry point for highly qualified individuals, particularly those with an MD or PhD, who demonstrate strong leadership and strategic thinking. What we look for: What I Look for in a CV and During an Interview When I’m reviewing CVs and conducting interviews, I’m looking for a combination of scientific rigor, practical skills, and personal attributes that indicate a strong fit for the demanding yet rewarding world of Medical Affairs. Your CV: Make It Stand Out The Interview: Your Opportunity to Connect My interviews typically start with a brief introduction from me to create a relaxed and inclusive atmosphere. Then, it’s your turn to walk me through your career journey, highlighting skills and experiences relevant to the job description. The conversation then transitions into a Q&A session. Here’s what I’ll be looking for: Your Turn to Ask: Show Your Interest The end of the interview is your critical opportunity to ask questions. This shows your genuine interest, engagement, and that you’ve thought deeply about the role and the company. Avoid asking about salary at this stage; that’s typically handled by HR or a recruitment agent (especially in regions like Japan, where agents often navigate this sensitive topic). Here are a couple of examples of thoughtful questions you might consider: Ultimately, I’m looking for the best fit for our team: a knowledgeable and collaborative colleague who can quickly become independent, and from whom we can all learn. Diverse teams with varied backgrounds and skillsets are, in my experience, the strongest. Are you considering a career in Medical Affairs, or perhaps looking to make a switch? What aspect of this field excites you the most?

Medical Affairs is a relatively “young” department within the pharmaceutical industry, yet it’s rapidly become an indispensable pillar. Having spent years navigating various roles within this evolving field—from a Medical Advisor to Franchise or TA Lead in a country organization, and most recently as a Regional Lead in Asia Pacific—I’ve witnessed firsthand its profound impact and unique appeal.

At Briefio, we’re all about maximizing efficiency and effectiveness in everything you do. What if we told you there’s a powerful, yet often overlooked, synergy that can supercharge your cognitive abilities and well-being? It’s the dynamic duo of combining listening and learning with exercise and sports. Recent scientific research provides compelling evidence that integrating physical activity with intellectual engagement isn’t just good for you – it’s a game-changer for your brain.